Behavioral teratology of mercury and its compounds.
نویسنده
چکیده
Mercury and its compounds have a wide spectrum of toxicities depending upon the chemical forms and modes of exposure. Among the various chemical forms, mercury vapor and methylmercury are well known and established as neurotoxic agents. Since the disasters in Minamata and Iraq, in which fetuses were more susceptible than adults to methylmercury exposure, much attention has been focused on prenatal exposure to mercury and its consequence. Recently postnatal effects of in utero exposure to methylmercury through fish (and marine mammals) consumption by mothers have been concerned and several epidemiological studies have been conducted. Therefore, one of the most seriously concerned issues is the postnatal effects of in utero exposure to methylmercury. Because of these observations in humans, animal experiments have been conducted employing prenatal exposure to low levels of mercury. This paper reviews the animal (rodents) experiments concerning "behavioral teratology" of mercury for better understanding of effects of prenatal exposure to mercury and its compounds in addition to commentary on history and framework of behavioral teratology.
منابع مشابه
Behavioral teratology: overview.
The field of teratology has expanded in recent years to include the effects of prenatal insult on the function of postnatal animals. This broadening of teratology reflects an awareness of the need to look for more subtle manifestations of developmental toxicity than gross morphologic changes. One aspect of postnatal function which is receiving a great deal of attention is called behavioral tera...
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It has recently been demonstrated that developmental exposure to methylmercury (MeHg) is associated with perseveration on operant tasks. An understanding of the behavioral mechanisms underlying this phenomenon may improve human testing of MeHg exposures and could provide insight into clinical syndromes that include perseveration as a component. One possible mechanism is that MeHg-induced enhanc...
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Recent experiments have suggested that developmental methylmercury exposure produces perseverative behavior in adulthood. In the present experiment, interactions between developmental low-level methylmercury (MeHg) and nutritionally relevant dietary selenium (Se) on operant behavior and its persistence were examined in aged animals. Female rats were exposed, in utero, to 0, 0.5, or 5 ppm mercur...
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ورودعنوان ژورنال:
- The Tohoku journal of experimental medicine
دوره 201 1 شماره
صفحات -
تاریخ انتشار 2003